WFDC2 and cancer: Moreover, we observed significant differences between the concentrations of all the parameters when every stage of cancer advancement (I-IV) was compared with the corresponding control group (with the exception of TIMP-1 – stage II): I -p < 0.001 (MMP-7, HE4 and CA125); II - p < 0.001 (in all cases); III - p < 0.001 (MMP-7, HE4 and CA125) and p = 0.001 (TIMP-1); IV - p < 0.001 (MMP-7, HE4 and CA125) and p = 0.011 (TIMP-1).