Plasma concentrations of all aforementioned biomarkers were also significantly different in the advanced stages (III-IV) in comparison to those found in the early stages (I-II): MMP-7, TIMP-1, HE4 and CA125 in the comparison of stage III with stage I (p = 0.037; p = 0.005; p = 0.011; p = 0.002, respectively) and HE4 and CA125 in the comparison of stage III with stage II (p = 0.004; p = 0.013) or MMP-7, TIMP-1 and CA125 in the comparison of stage IV with I (p = 0.011; p = 0.033; p = 0.007), MMP-7 and CA125 in the comparison of stage IV with II (p = 0.010; p = 0.025) of tumor advancement. This evidence concerns the gene MMP7 and neoplasm.