Furthermore, significant positive correlations were noticed between the HE4 and MMP-7 (R = 0.24; p = 0.008) or TIMP-1 (R = 0.27; p = 0.002) concentrations as well as between the MMP-7 and TIMP-1 concentrations (R = 0.25; p = 0.006) in the ovarian cysts group. This evidence concerns the gene TIMP1 and Ovarian cyst.