INPP5D and Alzheimer disease: Other gene variants associated with influencing AD risk that impact microglia function and complement signaling include CD33, CR1, ABCA7, SHIP1, BIN1, CD2AP, CLU, HLA-DRB5/DRB1, INPP5D, SORL1, EPHA1, PLD3, PICALM, and MS4A [2, 92, 93].