In contrast, other studies suggest an anti-apoptotic function for RBM10; (1) RBM10KD in SHSY5Y human neuronal cells augmented proapoptotic caspase activity after staurosporine exposure [18], (2) expression of both RBM10 mRNA variants in breast cancer cells positively correlated with VEGF mRNA, a promoter of new blood vessel growth [16], and (3) in patients with metastatic melanoma, high RBM10 expression correlated with increased disease aggressiveness [19]. Here, RBM10 is linked to metastatic melanoma.