PLAT and brain aneurysm: Some of these cases did not involve the complication of ICH during aneurysm rupture; other case series investigated the safety of r-tPA for patients with unruptured cerebral aneurysms, and noted that the asymptomatic and incidentally detected unruptured cerebral aneurysms did not increase the risk of post-r-tPA ICH [10–12, 25, 26].