FTO and obesity due to melanocortin 4 receptor deficiency: The haplotype analysis exhibited that the strongest obesity associated haplotype (χ2 = 11.474, p = 0.0007) which contained the minor alleles for SNPs distributed across a 45-kb stretch of intron 1 of FTO, was in block 8 and occurred at a frequency of 0.46 in the case group and 0.41 in controls.