This was associated with significantly improved clinical disease parameters between day 8 and 21, including weight loss (Fig 2A and 2B), systemic bacteremia (manifesting in live recoverability of C. rodentium from the spleen; Fig 2C), colonic mucosal histopathology (Fig 2D and 2E), and fecal concentrations of lipocalin-2 (a fecal marker for colitis severity; Fig 2F). The gene discussed is LCN2; the disease is bacterial infectious disease with sepsis.