The identified BioFunctions include Proliferation of tumor cell lines (14 DEGs), Invasion of cells (10 DEGs) and Migration of tumour cell lines (10 DEGs), with a common core of 5 validated genes (ATF3, CDKN1A, GDF15, HBEGF and LCN2) that may represent novel downstream effectors of the pro-oncogenic activities—proliferation, migration, invasion and/or apoptosis—transmitted through PI3K/AKT signaling. The gene discussed is ATF3; the disease is neoplasm.