SDC2 and osteosarcoma: Overexpression of syndecan-2 in osteosarcoma cells alters multiple pathways involving PI3K, mitogen-activated protein kinases, nuclear factor kappa-B (NF-kB) and protein kinase C δ, and also canonical and non-canonical Wnt pathways.14, 15, 16 On another hand, syndecan-2 supports neo-angiogenesis during development in zebrafish and in tumors, whereas shed syndecan-2 alters angiogenesis through the inhibition of endothelial cell migration.17, 18, 19 These data suggest that osteoblastic syndecan-2 could have a role in the relationship between angiogenesis and osteogenesis.20, 21, 22