This is a sterile model of sepsis that depends on RIPK1 kinase activity and RIPK3.42, 43 Sorafenib, administered by gavage 1.5 h before i.v. mTNF treatment, significantly protected mice from hypothermia and death caused by mTNF in a dose-dependent manner (Figures 5a and b). The gene discussed is RIPK3; the disease is Sepsis.