Cells and animals treated with aluminum (Al) exhibite a significantly reductions in neuronal viability, neurofibrillary tangle formation, and AD symptoms, which might serve as a model of AD.49, 50, 51, 52, 53 Nec-1 might protect against Al-induced cell death by reducing the phosphorylation of RIP1. The gene discussed is PCSK1; the disease is Alzheimer disease.