PCSK1 and Parkinson disease: The mitochondrial function-protective effects suggested that Nec-1 might have an antiapoptotic effect by stabilizing the mitochondrial membrane.58 The reversed effects on the levels of expression of LC3-II and cathepsin B in 6-OHDA-treated PC12 cells suggested that Nec-1 prevents autophagic cell death and downstream necroptotic signaling in the PC12 cells.58 However, based on these limited findings, it is still unknown whether Nec-1 has a protective effect in PD animal models.