TP53 and carcinoma: Loss of p53, The Guardian of the Genome, leads to polyploidy in a variety of cell types.44 In keratinocytes this loss induces polyploidy and squamous differentiation.10 The responses of the carcinoma cells studied here do not seem to be mediated by p53: (i) SCC12F cells seemingly bearing intact p53 become polyploid upon Nocodazole; (ii) BCCP displaying mutated p53 were able to efficiently control G2/M and ploidy; (iii) SCC12R2 cells overexpressing mutated p53 displayed no signs of polyploidy.