Interestingly, Galanos et al. now reports a role of chronic and p53-independent expression of p21 in promoting genomic instability through replication stress in carcinomas of lung of head and neck.45 Moreover, the deregulation of DNA replication licensing protein cdc6 contributes to features of epithelial–mesenchymal transition46 and deregulated Cyclin E was found to affect licensing.47 Here, CCNE1 is linked to carcinoma.