This is consistent with a previous study showing that KDM2B regulated the apoptotic response of pancreatic cancer cells.34 Our consistent results with multiple GBM cell lines and multiple proapoptotic agents such as TRAIL and BH3 mimetics suggest that KDM2B could be a global regulator of cell death in GBM cells. This evidence concerns the gene KDM2B and familial pancreatic carcinoma.