32 Similarly, KDM2B has been shown to regulate self-renewal capacity of cancer and cancer stem cells in hematological and pancreatic cancers, and its expression is positively correlated with advanced tumor grade.21, 22 A recent study displayed the protumorigenic role of KDM2B in a broad range of human tumors.33 To our knowledge, KDM2B has not been studied previously in brain malignancies and the present work is the first study to display its novel oncogenic role in GBMs. This evidence concerns the gene KDM2B and pancreatic neoplasm.