CDKN2B and acute myeloid leukemia: KDM2B is a H3K36me2 demethylase that is indicated as a regulator of cell growth.22, 30, 31 KDM2B, by its CxxC-ZF domain, can bind to CpG islands and can catalyze demethylation of H3K36 or H3K4 residues through its JmjC domain.24 KDM2B has been shown to be required for the tumorigenesis of acute myeloid leukemia, where it acts as an oncogene through silencing p15/Ink4b.