BCL2L1 and cancer: HRK is a BH3-only Bcl-2 family member that can antagonize antiapoptotic proteins Bcl-2 and Bcl-xL.25 While HRK’s role is mostly studied in nervous system,26, 27 its role in cancers, especially in GBM is not well defined.25 To assess the increased HRK expression upon KDM2B loss, we performed western blotting and observed increased HRK protein levels in shKDM2B cells compared with controls (Figure 4e).