SOCS1 and cancer: Indeed, aberrant SOCS1 CpG islands DNA methylation appears to be closely linked to their silencing during HCC metastasis, whereas epigenetic modifier drugs such as 5′-Aza can reactivate SOCS1 expression, indicating that epigenetic mechanisms have a functional role in controlling expression of this factor in cancers.4, 23 Therefore, miR-29a induces TET protein suppression leads to decreased expression of SOCS1 in HCC, this might be one mechanism for miR-29a promote HCC invasion and metastasis.