In addition, recent studies indicated that miR-29a specifically targets both DNA methyltransferases (DNMT3A and DNMT3B) in cancer.24, 25 The findings of our current study showed that a significant DNMT1, DNMT3A, and DNMT3B protein expressions increased in highly invasive HCCLM3 and MHCC97H cells compared with SMMC-7721 and HepG2 cells (Supplementary Figure S6A). The gene discussed is DNMT1; the disease is cancer.