In addition, PI-PLCγ1, activated by TLR4 stimulation with minimally oxidized LDL, induces ROS generation in macrophages, leading to the production of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6 [55], all having central roles in the pathogenesis of atherosclerosis [49]. The gene discussed is TNF; the disease is atherosclerosis.