NOS3 and metabolic syndrome: The above results are consistent with Senaphan et al. [9], who showed that ferulic acid alleviates changes in metabolic syndrome in rats through suppression of oxidative stress by down-regulation of p47phox, increased nitric oxide (NO) bioavailability with upregulation of endothelial nitric oxide synthase (eNOS) and suppression of TNF-α [9].