HFD significantly impaired angiogenesis, recovery and vascular density in WT but not TKO. To investigate the role of TXNIP in HFD-altered angiogenic response following ischemia, mice were fed HFD (60% fat) for 4 weeks, a time point of established insulin resistance, then were subjected to unilateral femoral artery ligation model. The gene discussed is TXNIP; the disease is Insulin resistance.