Thus, under acidotic conditions prevalent in sepsis, our in vitro studies suggest that, together with the inhibition by ascorbate of thrombin-induced platelet aggregation discussed above, inhibition by ascorbate of thrombin-induced PAI-1 release from platelets would yield a pro-fibrinolytic effect leading to dissolving of microthrombi in septic capillaries. This evidence concerns the gene SERPINE1 and Sepsis.