Pharmacological inhibition of mTORC1 with rapamycin in HFD-fed mice worsened glucose intolerance and AT inflammation by increasing the number of polarized M1 macrophages, naive and activated cytotoxic T lymphocytes, and proinflammatory markers such as TNF-α, IL-6, and MCP-1. This evidence concerns the gene IL6 and Glucose intolerance.