A recent study has reported the beneficial effects of NaSal in numerous experimental models of sepsis by triggering lipoxins, blocking microbial mediators of sepsis, reducing NF‐κB stimulation, and inhibiting septic pathways.42 The different effects may account for the different findings from models with nonsteroidal anti‐inflammatory drug (NSAID) intervention and further study is required to investigate the potential role of AMPK in NaSal‐mediated sepsis. This evidence concerns the gene PRKAA1 and Sepsis.