In this study, we first evaluated the correlation between AEG‐1 overexpression and metastasis of gastric cancer in human cancer specimens, then determined the role of AEG‐1 in EMT, migration, and invasion of gastric cancer cells in parallel with the detection of eIF4E expression, via overexpression or silencing of AEG‐1. This evidence concerns the gene EIF4E and gastric cancer.