Only one patient with MFN2 p.Leu710Pro mutation showed HMSN with significant spasticity and increased patellar tendon reflex, which is the HMSN V phenotype, while four patients with MFN2 p.Arg104Trp, p.Arg104Leu, and p.Arg364Trp mutations showed HMSN with optic atrophy. The gene discussed is MFN2; the disease is optic atrophy.