Similarly, observational data from a study of the Tayside insulin management (TIM) structured education programme showed a reduction in HbA1c (mean 0.4%; p < 0.001) following 6 months of participation, a reduction in the annual incidence of severe hypoglycaemia requiring parenteral treatment and improved awareness of hypoglycaemia in 25% of participants [32]. The gene discussed is INS; the disease is Hypoglycemia.