CD40 and diffuse large B-cell lymphoma: ChiLob 7/4 is an intermediate CD40 agonist and chimeric IgG1, which was also proved to induce the proinflammatory cytokine and gave promising results in phase 1 clinical studies in CD40-expressing solid tumors and diffuse large B-cell lymphoma resistant to conventional therapy (Chowdhury et al. 2014; Johnson et al. 2015).