More recently, genetic studies revealed that mutations in p97 may be causal to several human diseases including IBMPFD (Inclusion Body Myopathy associated with Paget's disease of the bone and Frontotemporal Dementia) and amyotrophic lateral sclerosis (ALS) (Xia et al., 2016). The gene discussed is VCP; the disease is inclusion body myopathy with Paget disease of bone and frontotemporal dementia.