While type 1 diabetes is considered an autoimmune disorder characterized by the destruction of the insulin-producing β cells in the pancreas by the immune system, type 2 diabetes in a multifactorial disease, where genetic predisposition and environmental/lifestyle factors result in decreased insulin sensitivity in skeletal muscles, liver, and adipose tissue and a progressive reduction in pancreatic insulin secretion (224). Here, INS is linked to type 2 diabetes mellitus.