IRS1 and Insulin resistance: In the regulation of insulin secretion, a role seems to be played by miR-29a and -29b through the silencing of monocarboxylate transporter in β-cells (232); moreover, this family of miRNAs is implicated in the development of insulin resistance in myocytes, through the repression of the insulin receptor substrate 1 (IRS-1), a key molecule in the insulin signaling (233).