The aim of this study was to test the ability of Ct to induce EMT-related processes in human conjunctival epithelial (HCjE) cells in vitro by analyzing the expression of selected relevant EMT inducers and marker genes (E-cadherin, fibronectin, α-SMA), and to investigate whether alterations in gene expression after Ct infection correlate with changes in their DNA methylation profiles and subsequent gene expression. The gene discussed is CDH1; the disease is infection.