The authors proposed that LGP2 regulatory role works as a concentration dependent biphasic switch, enhancing MDA5-mediated antiviral signaling at early stages of infection when LGP2 concentration is low, but as infection progresses and IFN induces LGP2 production, MDA5 signaling is inhibited (Bruns et al., 2013, 2014; Uchikawa et al., 2016). The gene discussed is DHX58; the disease is infection.