As compared to healthy control tissues, human CP specimens were characterized by a reduced abundance of the lipidated from of LC3 (LC3-II) (Figure 2g) and an accumulation of the autophagic substrate sequestosome-1 (STQM1/p62) (Supplementary Figure D, Table 2), indicating an overall reduced autophagy activity in human chronic pancreatitis samples. The gene discussed is SQSTM1; the disease is chronic pancreatitis.