GRP and cancer: However, they possess unfavourable pharmacokinetic properties, such as hepatic accumulation and hepatobiliary excretion.83 Conjugation of radiolabeled bombesin analogues with glucose moiety (through a triazole group) reduced abdominal accumulation and increased the uptake by tumours without affecting the cell internalisation of the modified peptides (Fig. 10).84 Glycosylation was applied to increase the hydrophilic property of radiolabeled Tyr(3)-octreotide peptide and overcome the drawbacks restricting its application in diagnostic imaging and cancer radiotherapy.