Their results showed that in SK-N-SH neuroblastoma cells, the fragment 1–185 of apoE4 regulates the levels of matrix metalloproteinase 9 (MMP9) and tissue inhibitor of metalloproteinase 1 (TIMP1) through the modulation of the level of inflammatory molecules: increases IL-1β and decreases IL-10 expression [80]. The gene discussed is MMP9; the disease is neuroblastoma.