APOE and Alzheimer disease: In a quadruple transgenic mice model for AD (mice bearing apoE4 as well as transgenes for APPSwe, PS1M146V and tauP301L) significant memory impairment and higher levels of amyloid β species, β-site APP cleavage enzyme (BACE-1) and one BACE-1 inducer -transcription factor Sp1 were revealed in the hippocampal tissue of female mice as compared to their male counterparts [73].