TP53 and osteosarcoma: Besides, the enhanced expression of p53 was shown to be important for TNT formation by MG63 osteosarcoma cell TNTs [49] while dispensable for TNT formation in other cell types as shown for PC12 cells, OCI-AML3 (acute myeloid leukemia) cells, human osteosarcoma cell line SAOS-2 (p53-null), and murine bone marrow-derived MSCs [66].