Moreover, FGF1 did not stimulate insulin release from the pancreatic islets or possess insulin-mimetic effects but could markedly enhance the glucose-lowering effects of exogenously supplied insulin in streptozotocin-induced type 1 DM (T1DM) mouse models [69], without affecting the blood glucose and insulin levels in chow-fed normoglycemic mice [68]. This evidence concerns the gene INS and type 1 diabetes mellitus.