NCR1 and ischemia reperfusion injury: A recent study revealed a hepatoprotective role of IL-22-producing RORγt+NKp46+ cells (NKp46+ILC3s) in hepatic ischemia reperfusion injury (IRI) through binding to the IL-22 receptor complex, which is overexpressed by stressed hepatocytes and leads to downstream activation of STAT3 and Akt (93), which represents a therapeutic strategy in hepatic IRI by the adoptively transfer of NKp46+ILC3s.