CD8A and viral infectious disease: Furthermore, upregulation of Dhx58 suggested the presence of LPG2, a RIG-I-like receptor that is required for controlling antigen-specific CD8+ T cell survival and fitness during peripheral T cell number expansion in response to virus infection (82), while upregulation of Tnfsf8 indicated the expression of CD135 which is the ligand for CD30 whose signaling plays important role in the generation of long-lived memory CD8+ T cells (83).