Thus, the multi-epitope peptides of CPA (CPA_p2 and CPA_p3) and histone H1 (H1_p1 and H1_p3) were linked together by AAY, a short amino acid motif that is documented to support epitope generation and has been used in several studies on epitope vaccine design against cancer or infectious diseases (56–59). This evidence concerns the gene H1-0 and infectious disease.