The therapeutic use of P10-primed DCs in our non-immunosuppressed murine PCM model also led to increased levels of IL-12 and reduced IL-10 levels in lung tissues, albeit high levels of IFN-γ were also present at the time the mice were euthanized in the prophylactic an therapeutic model (Magalhães et al., 2012). This evidence concerns the gene IFNG and paracoccidioidomycosis.