Compelling recent evidence suggests a direct link between type 2 ryanodine receptor (RyR2) dysfunction in the endo/sarcoplasmic reticulum leading to altered intracellular calcium homeostasis, glucose intolerance, and impaired insulin secretion in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) (36, 37). Here, INS is linked to catecholaminergic polymorphic ventricular tachycardia.