RYR2 and Glucose intolerance: Compelling recent evidence suggests a direct link between type 2 ryanodine receptor (RyR2) dysfunction in the endo/sarcoplasmic reticulum leading to altered intracellular calcium homeostasis, glucose intolerance, and impaired insulin secretion in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) (36, 37).