Similarly, a small open-label randomised trial (n = 50) also in the paediatric population found that standard insulin doses of 0.1 unit/kg/h compared to low dose 0.05 units/kg/h was associated with higher rates of hypoglycaemia (20 vs. 4%, p = 0.17), hypokalaemia (48 vs. 20%, p = 0.07), and cerebral oedema (4 vs. 0%), whilst time to reduction of blood glucose level and resolution of acidosis were similar (71). This evidence concerns the gene INS and brain edema.