For example, at 48 h after IS, mean serum IL-10 is significantly higher than in healthy or at-risk controls, and high IL-10 sera levels independently correlate with severe neurologic deficits (NIHSS ≥12) at 48 h post-stroke and predict major adverse clinical outcomes (recurrent IS, any cause of death, NIHSS ≥12) at 90 days (85). This evidence concerns the gene IL10 and stroke disorder.