MYBPC3 and cardiomyopathy: Furthermore, Jiang et al. suggest that in contrast to the homozygote cMyBP-Ct/t mouse, the hearts of individual human patients heterozygous for cMyBP-C mutations are purely hypertrophic, and the difference in allelic expression between the cMyBP-Ct/t and heterozygous patients results in divergent cellular pathways both leading to cardiomyopathy (Jiang et al., 2015).