NOTCH1 and stricture: Since the initial report, multiple NOTCH1, mostly missense, variants have been associated with BAV, BAV/TAA, aortic valve stenosis, coarctation, and hypoplastic left heart (Mohamed et al., 1797; McKellar et al., 2007; Iascone et al., 2012; Foffa et al., 2013; Freylikhman et al., 2014; Preuss et al., 2016; Irtyuga et al., 2017).