Our results revealed that after the activation of HIF-1α by CoCl2, SPC significantly upregulated the expression of HIF-1α, VEGF and eNOS, and thus improved the hemodynamic parameters (i.e., HR, LVDP, LVEDP, and +dp/dtmax), mitochondrial respiratory function (i.e., state III and the RCR), and enzymatic activities (NADH-OX, Suc-OX, and Ctyc-OX) and reduced the myocardial infarction area. Here, VEGFA is linked to myocardial infarction.