In this study, we demonstrated that after CoCl2 activated the damaged HIF-1α signaling pathway during diabetes, SPC could stabilize and upregulate HIF-1α and increase the expression of downstream VEGF and eNOS, thereby improving the respiratory function and enzyme activity of the mitochondria and reducing the production of ROS, which plays a role in myocardial protection. Here, VEGFA is linked to diabetes mellitus.