CYBB and Hyperglycemia: Indeed, ROS production by NOX2 can be stimulated by hyperglycemia in cardiomyocytes through SGLT1 (Balteau et al., 2011) and ROS may amplify intracellular signaling when glucose is elevated (Taylor et al., 1992; Ha and Lee, 2000; Tarng, 2002; Zuo et al., 2011).