UACC-903 (Wnorowski et al., 2015), C32 (Kang et al., 2013) and UACC-647 (Wnorowski et al., 2015) cell lines express high levels of phosphoactive ERK1/2 due to the activatory V600E substitution in upstream BRAF kinase (Alfano et al., 2008; Byron et al., 2012), a mutation common in melanomas (Moses et al., 2003). The gene discussed is MAPK3; the disease is melanoma.