IL18 and adult-onset Still disease: The IL-1 family comprises 11 members (Dinarello, 2011), and some investigators (Colafrancesco et al., 2012; Priori et al., 2014) have shown that IL-1α/β and IL-18 are crucial in the pathogenesis of AOSD and are valid serological biomarkers of the disease (Colafrancesco et al., 2015).