In this context, a key role of pro-inflammatory cytokines, such as IL-1β, in the development of cardiovascular complications of DM is being considered (Raines and Ferri, 2005; Goldberg, 2009; Sprague and Khalil, 2009; Frostegård, 2013; Krishnan et al., 2014). Here, IL1B is linked to diabetes mellitus.