However, its clinical indications have been extended so far to other diseases such as the cryopyrin-associated periodic syndromes (CAPS), a group of rare inherited auto-inflammatory diseases associated to pathogenic variants in the IL-1-regulating genes NLRP3 and ILRN (Jesus and Goldbach-Mansky, 2014). The gene discussed is NLRP3; the disease is cryopyrin-associated periodic syndrome.