Transgenic activation of kallikrein-1 ameliorated intramyocardial inflammation through reduction of adhesion molecules, IL-1β and TNF-α, and leukocyte infiltration, as well as endothelium dysfunction and oxidative stress in T1DM-induced diabetic cardiomyopathy (Tschöpe et al., 2005). Here, IL1B is linked to diabetic cardiomyopathy.