In addition, a glucocorticoid (methylprednisolone) treatment reduced expression of TLR4/NF-κB signaling and IL-1β, IL-6, TNF-α, and ICAM-1 on T1DM-induced diabetic cardiomyopathy with I/R injury (Hu et al., 2011). Here, TLR4 is linked to type 1 diabetes mellitus.