CD63+ and caveolin-1+ are mutually related, and in conjunction with other biomarkers, such as p-Met, TYRP2, HSP70, HSC70, and VLA-4, this association increases the predictive accuracy of early diagnosis and prognosis of melanoma (Logozzi et al., 2009; Peinado et al., 2012). Here, CD63 is linked to melanoma.