AKT1 and cancer: Chemo-potentiation of microtubule disrupting agents (e.g., docetaxel and paclitaxel) by TQ was found to be mediated by upregulation of tumor suppressor genes such as p21 and Brca1, induction of pro-apoptotic factors, and inhibition of cancer cell growth and survival promoting signaling pathways such as PI3K/Akt and MAPK/ERK (Dirican et al., 2015; Sakalar et al., 2016).