ERBB2 and cancer: Despite the emergence of numerous treatment strategies such as chemotherapeutic agents, small molecule inhibitors, specific gene, or protein targeting so-called smart drugs, and immunotherapies that are found to be effective in the treatment of some form of cancers (e.g., childhood leukemia, human epidermal growth factor receptor 2-positive breast cancer), cancer death rate, in general, has not changed substantially (only 5% since 1950; Sung et al., 2012).