Interestingly, a few studies have suggested that 5-HT6 receptor antagonists may reduce anxiety and depressive-like behavior in rodent models (Wesolowska and Nikiforuk, 2007; Wesolowska and Jastrzebska-Wiesek, 2011), although the combined effects of 5-HT6 antagonists with AChEIs have not been tested. The gene discussed is HTR6; the disease is Anxiety.