These negative data regarding the endocannabinoids AEA and 2-AG are, however, in agreement with the lack of changes in ghrelin levels in hedonic eating in PWS patients, as discussed above, thus corroborating previous evidence on the existence of direct correlations between ghrelin secretion and endocannabinoid production [9,13]. The gene discussed is GHRL; the disease is Prader-Willi syndrome.