The results of efficacy and safety from 3 controlled trials of PsA [181–183] and 2 trials of AS [184, 185], respectively, enrolling a total number 1045 and 620 patients, led to the approval of SCK, a fully human monoclonal antibody targeting and neutralizing IL-17A, for the treatment of the two rheumatic disorders. Here, IL17A is linked to rheumatic disorder.