In recent years, non-anti-TNF-targeted biologics, including anti-interleukin- (IL-) 1 anakinra (ANK), IL-6 inhibitor tocilizumab (TCZ), anti-CD20 rituximab (RTX), anti-CD28 abatacept (ABA), anti-IL-12 and IL-23 (UTK), and anti IL-17 secukinumab (SCK), were licensed for the treatment of RA (ANK, TCZ, RTX, and ABA), AS (UTK), and PsA (UTK and SCK). This evidence concerns the gene CD28 and rheumatoid arthritis.